研究方向与兴趣 Main Research
单分子酶学，合成生物学，代谢工程，酶工程，人工智能
Single-molecule Enzymology, Synthetic Biology, Metabolic Engineering, Enzyme Engineering, Artificial Intelligence
学术成果 Publications
1、代表作：
(1) Zhang Aihui#, Zhuang Xiaoyan#, Liu Jia#, Huang Jiacheng#, Lin Luchun, Tang Yongxiang, Zhao Shiqiang, Li Ruihao, Wang Binju*, Fang Baishan*, Hong Wenjing*. Catalytic cycle of formate dehydrogenase captured by single-molecule conductance. Nature Catalysis, 2023, 6: 266-275. (IF=40.706，ESI Highly Cited)
(2) Wang Kaifeng, Zhao Wenyang, Lin Lu, Wang Tianjing, Wei Ping, Ledesma-Amaro Rodrigo, Zhang Aihui*, Ji Xiaojun*. A robust soft sensor based on artificial neural network to monitor microbial lipid fermentation process by Yarrowia lipolytica. Biotechnology and Bioengineering, 2023, 120: 1015-1025.
(3) Zhang Aihui#, Zhu Kaiyi#, Zhuang Xiaoyan, Liao Langxing, Huang Shiyang, Yao Chuanyi*, Fang Baishan*. A robust soft sensor to monitor 1,3-propanediol fermentation process by Clostridium butyricum based on artificial neural network. Biotechnology and Bioengineering, 2020, 117(11): 3345-3355.
(4) Zhang Aihui, Zhuang Xiaoyan, Chen Kainan, Huang Shiyang, Xu Chaozhen, Fang Baishan*. Adaptive evolution of Clostridium butyricum and scale-up for high-concentration 1,3-propanediol production. AIChE Journal, 2019, 65(1): 32-39.
(5) Zhang Aihui, Huang Shiyang, Zhuang Xiaoyan, Wang Ke, Yao Chuanyi*, Fang Baishan*. A novel kinetic model to describe 1,3-propanediol production fermentation by Clostridium butyricum. AIChE Journal, 2019, 65(6): e16587.
2、其他第一作者（含共同第一作者#）/通讯*（含共同通讯*）论文：
(6) Huang Jiacheng, Li Chade-Deng, Zhao Haodong, Yu Meng, Zhang Aihui*, Fang Baishan*. Artificial intelligence system for enhanced automated 1,3-propanediol green biosynthesis. Green Chemistry, 2023, 25: 9175-9186.
(7) Zhang Aihui, Liu Haolin, Huang Shiyang, Fu Yousi, Fang Baishan*. Metabolic profiles analysis of 1,3-propanediol production process by Clostridium butyricum through repeated batch fermentation coupled with activated carbon adsorption. Biotechnology and Bioengineering, 2018, 115: 684-693.
(8) Zhuang Xiaoyan#, Zhang Aihui#, Qiu Siyao, Tang Chun, Zhao Shiqiang, Li Hongchun, Zhang Yonghui, Wang yali, Wang Binju, Fang Baishan*, Hong Wenjing*. Coenzyme coupling boosts charge transport through single bioactive enzyme junctions. iScience, 2020, 23(4): 101001.
(9) Ji Xiaojun#, Zhang, Aihui#, Zhikui Nie, Wenjia Wu, Lujing Ren, He Huang*. Efficient arachidonic acid-rich oil production by Mortierella alpina through a repeated fed-batch fermentation strategy. Bioresource Technology, 2014,170: 356-360.
(10) Zhang Aihui, Ji Xiaojun*, Wu Wenjia, Ren Lujing, Yu Yadong, Huang He*. Lipid fraction and intracellular metabolite analysis reveal the mechanism of arachidonic acid-rich oil accumulation in the aging process of Mortierella alpina. Journal of Agricultural and Food Chemistry, 2015, 63: 9812-9819.
(11) Zhuang Xiaoyan#, Wu Qian#, Zhang Aihui#, Liao Langxing, Fang Baishan*. Single-molecule biotechnology for protein researches. Chinese Journal of Chemical Engineering, 2021, 30: 212-224.
(12) Chen Junhong, Zhuang Xiaoyan, Zheng Jiyang, Yang Ruofan, Wu Fei, Zhang Aihui*, Fang Baishan*. Aptamer-based cell-free detection system to detect target protein. Synthetic and Systems Biotechnology, 2021, 6: 209-215.
(13) Bi Ruomeng, Ou Meihao, Zhou Siru, Geng Shichen, Zheng Yixian, Chen Junhong, Mo Ruijie, Li Yuan, Xiao Gezhi, Chen Xingyu, Zhai Shiyi, Zhang Aihui*, Fang Baishan*. Degradation strategies of pesticide residue: From chemicals to synthetic biology. Synthetic and Systems Biotechnology, 2023, 6: 209-215.
(14) 毛金竹, 肖淑玲, 杨智淳, 王孝宇, 张诗, 陈俊宏, 谢佶晟, 陈福德, 黄子诺, 冯天宇, 张瑷珲*, 方柏山*. 合成生物学在农残检测领域的应用. 化工学报, 2021, 72(05): 2413-2425.
教育背景 Education
(1) 工学博士，生物化工，2016.09-2019.09，厦门大学，
导师：方柏山 教授（闽江特聘学者）
Ph. D. of Science, Biochemical Engineering, 09. 2016-09. 2019,
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, P. R. China (Prof. Baishan Fang).
(2) 理学硕士，微生物学，2012.09-2015.06，南京工业大学，
导师：黄和 教授（院士）
Master of Science, Microbiology, 09. 2012-06. 2015,
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, P. R. China (Prof. He Huang).
(3) 黄山学院，生物技术，2008.09-2012.06
Bachelor of Science, Biotechnology, Huangshan University, 09. 2008-06. 2012,
研究经历 Research Experience
(1) 博士后，物理化学，厦门大学，2019.12-2022.10。
Post-doctor, Physical Chemistry, 12. 2019-10. 2022.
(2) 工程师，厦门大学，2022.12-2023.2。
Engineer, College of Chemistry and Chemical Engineering, Xiamen University, P. R. China, 12. 2022-02. 2023.
(3) 副研究员，厦门大学，2023.03-今。
Associate Research Fellow, College of Chemistry and Chemical Engineering, Xiamen University, P. R. China, 03. 2023-Now.
主持项目 (Project)
(1) 中国人力资源和社会保障部，国家博士后创新人才支持计划，已结题，400人/年。
(2) 国家自然科学基金青年项目，在研，2023-2026。
获奖情况 (Honours and Awards)
(1) 2021年，用于1,3-丙二醇生产的丁酸梭菌发酵代谢轮廓分析和适应性进化研究，福建省教育厅，福建省优秀博士论文。
(2) 2020年，1,3-丙二醇反复分批发酵过程代谢轮廓分析，福建省教育厅，第十四届福建省自然科学优秀学术论文，三等奖。
(3) 2020年，厦门大学，优秀毕业生。
会议 (Conference Presentations)
(1) 2023年，第七届全国化学工程与生物化工年会，优秀青年报告奖。
(2) 2023年，生物工程学科发展战略研讨会，优秀报告奖
(3) 2023年，第六届生物化学青年学者论坛，优秀报告奖
学术兼职 (Academic Responsibilities and Professional Obligations)
(1) 中国生物化工青年学者工作委员会委员（2023-2027）
(2) 厦门市生物化学与分子生物学协会理事（2024-2029）
